In the film The Agent of C.I.P.O.L., the Cold War is in full swing and the Iron Curtain has not yet fallen. That is why we are going to witness the operation U.N.C.L.E. Which involves many people, but mainly two agents.
One is Napoleon Solo of the CIA and the other is Illya Kuryakin of the KGB. Both are declared enemies, but the truth is that they will have to understand well and soon if they want to protect the interests of their respective countries.
The blame is a criminal organization that covers the whole world and wants to destabilize it, using nuclear technology. In this way, both agents have to smooth their roughnesses fast.
The only clue they have is the daughter of a scientist, who seems to be the key so that the two can infiltrate the organization and destroy it from within, which seems the only way they have to be able to do so.